Kornsuda Thipart1,
Kutcharin Phunikhom1,
Acharaporn Na Lampang Noenplab2,
Jintana Sattayasai1 
For correspondence:- Jintana Sattayasai Email: sjinta@kku.ac.th Tel:+6643348397
Accepted: 28 February 2020 Published: 31 March 2020
Citation: Thipart K, Phunikhom K, Noenplab AN, Sattayasai J. Dark Purple Luem Pua rice extract reduces disease severity in rat models of inflammatory bowel disease. Trop J Pharm Res 2020; 19(3):629-636 doi: 10.4314/tjpr.v19i3.25
© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the effects of an aqueous extract of unpolished dark purple glutinous Thai rice, variety Luem pua (LP), in two rat models of inflammatory bowel disease (IBD).
Methods: Polyphenolic compounds content were determined by HPLC methods and antioxidant activities by DPPH and FRAP assays of the LP extract. The effect of the LP extract at 5 g/kg/day were evaluated in two rat models of IBD that included acetic acid and indomethacin induced IBD. On each day of treatment, changes of body weight, stool consistency and stool blood were scored and expressed as disease activity index (DAI). At the end of the experiments, the animals were euthanized. Colon length and spleen weight were determined, and the degree of inflammation of the colon was scored.
Results: Rats in both models of IBD (acetic acid- and indomethacin-induced IBD), exhibited significant increases in DAI, macroscopic inflammation scores and spleen weights, while the lengths of colon were decreased. Pretreatment with LP extract attenuated the disease severity in both models as seen by the reverse of all observed altered parameters.
Conclusion: These data suggest that LP extract might be beneficial in preventing and/or treating IBD
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